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| Effect of Yanting Granules on TNF-α secretion of spleen cells induced by lipopolysaccharide in mice |
| Hits 1628 Download times 1710 Received:October 10, 2008 |
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| DOI
10.11656/j.issn.1672-1519.2009.02.26 |
| Key Words
Yanting Granules;LPS;spleen cell;TNF-α |
| Author Name | Affiliation | | CAI Jing | Yantai Harbor Hospital, Yantai 264000, China | | QI Bing | Heilongjiang University of TCM, Haerbin 150040, China | | HOU Li-hui | Heilongjiang University of TCM, Haerbin 150040, China | | 吴效科 | Heilongjiang University of TCM, Haerbin 150040, China |
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| Abstract
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| [Objective] To explore the effect of a compound prescription of Chinese medicine Yanting Granules on TNF-α secretion of spleen cell induced by lipopolysaccharide(LPS) in mice and the immunoregulation of Yanting Granules in treating chronic pelvic inflam-matory disease (CPID). [Methods] TNF-α expression in spleen cells of mice was induced by LPS and spleen cells of mice were treated with medicine-contained serum of Yanting Granules. TNF-α synthesis was detected using ELISA and RT-PCR. [Results] Compared with the normal group,the secretion of TNF-α was significantly increased in LPS group. Medicine-contained serum of different concentrations could reduce the secretion of TNF-α. [Conclusion] The results suggest that the resistance function of Yanting Granules against the in-flammation and immunoregulation may be related to the inhibitory effect of the release of TNF-α secretion. |
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