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| Research on relationship between the seasonal changes and the second messengers of lung in normal rats |
| Hits 2411 Download times 1931 Received:March 05, 2009 |
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| DOI
10.11656/j.issn.1672-1519.2009.03.06 |
| Key Words
Season;second messengers;melatonin;lung corresponding with autumn |
| Author Name | Affiliation | | GU Xiao-jing | College of Basic Medical Sciences, Beijing University of TCM, Beijing 100029, China | | MA Shu-ran | College of Basic Medical Sciences, Beijing University of TCM, Beijing 100029, China | | Guo Xia-zhen | College of Basic Medical Sciences, Beijing University of TCM, Beijing 100029, China | | 袁卫玲 | 天津中医药大学基础医学院, 天津, 300193 | | 刘晓燕 | College of Basic Medical Sciences, Beijing University of TCM, Beijing 100029, China | | 赵树宏 | College of Basic Medical Sciences, Beijing University of TCM, Beijing 100029, China |
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| Abstract
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| [Objective] From observing the changes of cAMP,cGMP and lung IP3 of male rats in four seasons,we can investigate the effects of the seasonal changes on the second messengers of lung of normal rats. [Methods] The level of cAMP and cGMP of lung tissue was determined by ELISA,IP3 of lung tissue was detected by RIA. [Results] The cAMP level of lung in male rats in winter solstice was obviously higher than those in autumnal equinox(P<0.05),and there was a trend that the level of cAMP was decreased in the order of summer,spring,winter and autumn. The cGMP level of lung in male rats in vernal equinox was significantly lower than those in autumnal equinox(P<0.01). The level of cGMP of lung in male rats was obviously lower than those in autumnal equinox(P<0.05),and there was a trend that the level of cGMP was decreased in the order of autumn,winter,summer and spring. No statistical difference in the level of IP3 was found between four seasons,but the level of IP3 in winter solstice was the lowest. [Conclusion] In autumnal equinox,the level of cAMP is the lowest,the level of cGMP is he highest,and the level of IP3 in winter solstice is the lowest. It may be one of the pathophysiologic basis of respiratory diseases mostly happened in autumn and winter,and the secreted melatonin by pineal gland may be related to the seasonal changes. |
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