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| Effects of Rheumatoid Arthritis No.1 on expression of VEGF and COX-2 in synovial membrane in rats with adjuvant arthritis |
| Hits 1535 Download times 1744 Received:November 20, 2008 |
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| DOI
10.11656/j.issn.1672-1519.2009.03.28 |
| Key Words
rheumatoid arthritis;rats;VEGF;COX-2 |
| Author Name | Affiliation | | ZHANG Yan | The First Hospital Affiliated to Zhejiang University of TCM, Hangzhou 310006, China | | SONG Xin-wei | The First Hospital Affiliated to Zhejiang University of TCM, Hangzhou 310006, China | | WU Ling-yan | The First Hospital Affiliated to Zhejiang University of TCM, Hangzhou 310006, China | | 康海英 | The First Hospital Affiliated to Zhejiang University of TCM, Hangzhou 310006, China | | 孙伟 | The First Hospital Affiliated to Zhejiang University of TCM, Hangzhou 310006, China |
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| Abstract
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| [Objective] To explore the effects of Rheumatoid Arthritis No. 1 on expression of VEGF and COX-2 in synovial membrane in rats with adjuvant arthritis(AA). [Methods] The model of adjuvant arthritis was established in rats. After administration by Rheumatoid Arthritis No. 1,for 4 weeks the immunohistochemical method was used to detect the expression of VEGF and COX-2 in synovial membrane of rats. [Results] The expression of VEGF and COX-2 in Rheumatoid Arthritis No. 1 group was significantly decreased compared to the groups of model and tripterygium wilfordii(P<0.01). [Conclusion] Rheumatoid Arthritis No.1 can significantly inhibit the expression of VEGF and COX-2 in synovial membrane of rate with adjuvant arthritis,reduce the inflammation of knee joint. |
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