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| Effect of Suxiao Jiuxin pellet on the expression of SDF-1/CXCR4 in atherosclerosis rats |
| Hits 1664 Download times 1550 Received:December 04, 2008 |
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| DOI
10.11656/j.issn.1672-1519.2009.03.31 |
| Key Words
Suxiao Jiuxin Pellet;atherosclerosis;SDF-1;CXCR4 |
| Author Name | Affiliation | | ZHANG Xiu-qin | The General Hospital of Tianjin Medical University, Tianjin 300052, China | | QU Zhu-qiu | The General Hospital of Tianjin Medical University, Tianjin 300052, China | | WANG Sha-sha | The General Hospital of Tianjin Medical University, Tianjin 300052, China |
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| Abstract
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| [Objective] To investigate the effect of Suxiao Jiuxin(improving the heart function with a high speed) Pellet on the expression of SDF-1/CXCR4 in rats with atherosclerosis and to find it’s mechanism of anti-atherosclerosis. [Methods] Atherosclerosis was established in rats by feeding with atherogenic diet and intraperitoneal injecting with vitamin D3 as a bolus. Sixty SD rats were randomly divid-ed into 6 groups:normal group(N),AS model group(Mo),Suxiao Jiuxin pellet low(SXL),medium(SXM),high(SXH) dosage group and Astorvastain group(ATO). Twelve weeks later,the pathological change of Aortas was analyzed by Image Pro Plus system;SDF-1 and CXCR4 were examined by immunohistochemistry. [Results] Compared with Mo,the SXM,SXH and ATO could significantly reduce the arterial intima and media thickness,SMH could also inhibit the proliferation of the collagen fiber and decrease percentage in vessel wall;SXL,SXH,SXN and ATO could decrease the expression of SDF-1 and CXCR4;Between ATO,SXM and SXH there were no significant difference(P>0.05). [Conclusion] Suxiao Jiuxin Pellet(medium,high dosage) can prevent the proceeding of AS by reducing the arterial thickness,inhibiting proliferation of the collagen fiber,delaying the process of AS. |
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