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| Correlation between differentiated classification of chronic aplastic anaemia and Fas/FasL protein expression |
| Hits 2474 Download times 1926 Received:April 19, 2009 |
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| DOI
10.11656/j.issn.1672-1519.2009.04.07 |
| Key Words
chronic aplastic anemia;differentiation of symptoms and signs for classification;Fas protein;FasL protein |
| Author Name | Affiliation | | LIU Bao-shan | The First Affiliated Hospital of Tianjin university of TCM, Tianjin 300193, China | | GU Min-hua | The Hospital of Humen of TCM, Humen 523902, China | | WANG Xing-li | The First Affiliated Hospital of Tianjin university of TCM, Tianjin 300193, China | | 戴锡孟 | 天津中医药大学, 天津, 300193 |
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| Abstract
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| [Objective] To study the correlation between differentiated classification of chronic aplastic anaemia and Fas/FasL protein expression, to analyze the material basis of differentiation of cases with chronic aplastic anemia by TCM. [Methods] Ninety patients of chronic aplastic anemia, including 30 cases of asdthenic splenonephro-yang, 30 cases of kidney asthenia of both yin and yang, 30 cases of hepatic and renal yin deficiency, were selected in this study. The Fas/FasL protein expression in the bone marrow of CAA was detected by western blot. [Results] Fas/FasL protein expression in bone marrow of chronic aplastic anemia patients was higher than control (P<0.05, P<0.01). Among these three syndromes, Fas/FasL expression of hepatic and renal yin deficiency was the highest, patients with deficiency of both yin and yang was higher, asdthenic splenonephro-yang was high, all had significant difference (P<0.05,P<0.01). [Conclusion] The differentiation of cases by traditional Chinese medicine and Fas/FasL protein expression of chronic aplastic anaemia was correlative, Fas/FasL protein can be represented as the substantial basis of the syndrome differentiation of CAA. |
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