|
| Therapy of salvianolic acid B on diabetic atherosderosis(AS) in almlilmprotein E-gene knockout mice |
| Hits 1758 Download times 1853 Received:March 22, 2009 |
| View Full Text View/Add Comment Download reader |
| DOI
10.11656/j.issn.1672-1519.2009.05.31 |
| Key Words
salvianolic acid B;ApoE;diabetic atherosclerosis |
| Author Name | Affiliation | | GU Li-yan | Tianjin University of TCM , Tianjin 300193, China | | WANG Yu-chun | Tianjin University of TCM , Tianjin 300193, China | | FAN Ying-chang | 天津中医药大学, 天津, 300193 | | 鲍丽颖 | 天津中医药大学, 天津, 300193 | | 张洁 | 天津中医药大学, 天津, 300193 |
|
| Abstract
|
| [Objective] To observe the effect of Salvianolic acid B on diabetic atherosclerosis in Apolipoprotein E (ApoE)-gene knocked mice. [Methods] eight-week old mice were given intraperitoneal injection with stz and fed with high fat diet for 12-weeks to establish a diebatic atherosderosis model,then assigned them randomly into three groups:model group (fed with saline) Salvianolic acid B group (fed with Salvianolic acid B )and atorvastatin calcium positive control group (2.3 mg/kg everyday). After treating for 8 weeks,all the mice were killed and the aortas were stripped for morphological research and photograph analysis. [Results] In model group,some plaques were bigger,merged into flake,aortic wall thickened diffusively. Compared with that,In Salvianolic acid B treatment group and Lovastatin positive control group,the aortic sinus had a more limited plaque lesion. Morphological research showed that As lesions were found in aortas of model group and Salvianolic acid B group. The lesions of model group were more serious than those of Salvianolic acid B group. [Conclusion] Salvianolic acid B can relieve the diabetic As lesions of the ApoE gene knockout mice. |
|
|
|
|
|
|
|
