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| The effects of different penetration enhancers on transdermal behavior of Baicalin in rat in vitro |
| Hits 1898 Download times 1826 Received:April 11, 2009 |
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| DOI
10.11656/j.issn.1672-1519.2009.05.32 |
| Key Words
penetration enhancer;Baicalin |
| Author Name | Affiliation | | ZHAO Zheng | Tianjin University of TCM, Research institute of Traditional Chinese Medicine, Tianjin, China
Tianjin University of TCM, Engineering Research Center of Modern Chinese Medicine Discovery and Preparation Technique, Ministry of Education, Tianjin, 300193, China | | SONG Xi-wei | Tianjin University of TCM, Research institute of Traditional Chinese Medicine, Tianjin, China
Tianjin University of TCM, Engineering Research Center of Modern Chinese Medicine Discovery and Preparation Technique, Ministry of Education, Tianjin, 300193, China | | LIU Zhi-dong | Tianjin University of TCM, Research institute of Traditional Chinese Medicine, Tianjin, China
Tianjin University of TCM, Engineering Research Center of Modern Chinese Medicine Discovery and Preparation Technique, Ministry of Education, Tianjin, 300193, China |
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| Abstract
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| [Objective] To study the effects of Lab,Trans P and PG on the transdermal behavior of Baicalin in rat. [Methods] The Franz modified diffusion chamber was applied for evaluating the effect of different concentrations of each penetration enhancer (PE) on the permeability of Baicalin in vitro. [Results] Compared with control (P<0.05),3% Trans P and 5% PG could increase the apparent permeability as much as 3.15 and 3.05 folds. The penetration rate with the PE:3%Trans P>5%PG>7%PG>5%TransP>7%TransP>3%PG>1% TransP>10%PG>5%Lab. [Conclusion] The enhance effect of 3%TransP and 5%PG is significant,and is likely to apply in the further re-search. |
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