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| Study on extracorporal dissolution of baicalin extended-release tablets |
| Hits 2365 Download times 2096 Received:March 22, 2009 |
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| DOI
10.11656/j.issn.1672-1519.2009.05.33 |
| Key Words
baicalin;extended-release tablets;dissolution |
| Author Name | Affiliation | | GAO Guo-yi | Research institute of TCM, Tianjin University of TCM, Tianjin, 300193, China | | LIU Zhi-dong | Tianjin University of TCM, Engineering Research Center of Modern Chinese Medicine Discovery and Preparation Technique, Ministry of Education, Tianjin, 300193, China | | ZHAO Zheng | Research institute of TCM, Tianjin University of TCM, Tianjin, 300193, China |
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| Abstract
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| [Objective] To establish a UV method to determine the dissolution of baicalin extended-release tablets and determine its release mechanism in vitro. [Methods] The extracorporal dissolution of baicalin extended-release tablets was determined by UV method,the factors that influence drug release were determined by single factor investigation. [Results] Both qualification and dosage of HPMC had significant influence on the rate of drug release. The release curve in vitro of baicalin extended-release tablets fitted Higuchi equation fundamentally. [Conclusion] The UV method is simple and quick,the extracorporal dissolution show that the prescription of the extend-ed-release tablets is reasonable relatively,it was worthy for further research. |
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