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| Effects of Chaibei Zhixian Decoction on the expressions of MDR1 in intractable epileptic rats |
| Hits 1395 Download times 2067 Received:April 18, 2009 |
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| DOI
10.11656/j.issn.1672-1519.2009.06.14 |
| Key Words
intractable epilepsy;multiple drug resistance gene 1;Chaibei Zhixian Tang;carbamazepine |
| Author Name | Affiliation | | LIU Jin-min | Emergency Department of Dongfang Hospital of Beijing University of TCM, Beijing 100078, China | | ZHENG Xiang-chun | Emergency Department of Dongfang Hospital of Beijing University of TCM, Beijing 100078, China |
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| Abstract
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| [Objective] To investigate the effects of Chaibei Zhixian decoction, a Chinese herbal compound, on the expression and distribution of multiple drug resistance gene 1 (MDR1) mRNA in intractable epileptic rats, to explore the possible molecular pathogenesis mechanism of the intractable epilepsy. [Methods] The average duration of seizures and the Racine’s stage of epileptic seizure under different drug’s intervention were observed to judge and analyze their effects. Real-time PCR was used to compare the expression and distribution of MDR1 in the hippocampus and cerebral cortex of the rats. [Results] Compared with the normal group, the expression of MDR1 mRNA was significantly elevated in all epileptic groups. ( P<0.05). [Conclusion] Spontaneous recurrent seizure can induce the expression of MDR1 in the hippocampus and cerebral cortex in chronic intractable epileptic rats. The Chinese herbal compound Chaibei Zhixian Tang had some efficacy in inhibiting MDR1 drug transporters. |
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