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| Influence of gastrodine on amino acid transmitter in hippocampus of pentylenetetrazole-induced epileptic rats |
| Hits 1823 Download times 1713 Received:August 26, 2009 |
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| DOI
10.11656/j.issn.1672-1519.2009.06.15 |
| Key Words
epilepsy;gastrodine;glutamic acid;γ-aminobutyric acid;pentylenetetrazole |
| Author Name | Affiliation | | CHEN Xiao-yin | Department of Neurology, the Second People’s Hospital in Jingzhou City of Hubei Province, Jingzhou 434000, China | | TIAN Li-yi | Department of Neurology, the Second People’s Hospital in Jingzhou City of Hubei Province, Jingzhou 434000, China |
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| Abstract
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| [Objective] To explore the possible antiepileptic mechanism of gastrodine. [Methods] The expressions of glutamic acid and γaminobutyric acid in the hippocampus of pentylenetetrazole (PTZ)-induced epileptic rats and epileptic rats treaded with gastrodine were determined by SP method. [Results] The expression of glutamic acid in the hippocampus of PTZ group rats was higher than that of control group. After treatment with gastrodine, the glutamic acid expression was decreased significantly. There was no significant difference in the expression of glutamic acid between the rats of gastrodine group and normal control group. The expression of γ-aminobutyric acid in the hippocampus of PTZ group rats was lower than that of control group rats. After treatment with gastrodine, the expression of γaminobutyric acid was increased significantly. There was also no significant difference between the rats of gastrodine group and normal control group. [Conclusion] Gastrodine may reduce the excitability of cerebral cortices by inhibiting the activities of glutamic acid and by promoting the activities of γ-aminobutyric acid in the hippocampus, so the development and formation of epilepsy were inhibited. |
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