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| Effect of ShenQi Compound Prescription on myocardial cell Bcl-2, Bax and NO of GK rats |
| Hits 1516 Download times 2149 Received:September 09, 2009 |
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| DOI
10.11656/j.issn.1672-1519.2009.06.20 |
| Key Words
Shenqi Compound Prescription;GK rats;diabetic mellitus;myocardial damage;myocardial apoptosis;experimental research;treatment of traditional Chinese medicine |
| Author Name | Affiliation | | KANG Jian | 成都中医药大学附属医院肛肠科 成都 610075 | | LIU Ya | Chengdu University of TCM, Chendu 610075, China | | XIE Chun-guang | 成都中医药大学附属医院 成都 610075 | | 殷丽平 | Chengdu University of TCM, Chendu 610075, China |
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| Abstract
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| [Objective] To research the effective mechanisms of ShenQi Compound Prescription having action on myocardial cell Bcl-2, Bax and NO in GK rats (Goto-Kakizaki wistar rats) of T2DM. [Methods] The DCM was induced in rats by i.p. injecting Nω-nitio-L-arginine methyl ester (L-NAME) and gavaging high fat diet. The GK rats (RBS≥11.1 mmol/L)were divided into four groups: model control group, ShenQi Compound Prescription high-dose group, ShenQi Compound Prescription low-dose group, control group, at the same time cure group treated by ShenQi Compound Prescription for four weeks to observe the common state, the levels of NO of myocardium, Bcl-2 and Bax proteinum expression.[Results] ShenQi Compound Prescription could ameliorate GK rats’ common state, increase NO of myocardium, increase the expression of Bcl-2 protein, inhibit the Bax protein expression, adjust Bax/Bcl-2 protein expression. [Conclusion] Diabetic myocardial damage was associated with NO, Bax and Bcl-2 protein. Shenqi Compound Prescription can increase NO level, increase the expression of Bcl-2 protein and inhibit the Bax protein expression of myocardium. |
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