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| Effect of ginkgo biloba extract EGB761 on liver weight and morphology in hypercholesterolemia rabbits |
| Hits 1953 Download times 1815 Received:September 11, 2009 |
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| DOI
10.11656/j.issn.1672-1519.2009.06.21 |
| Key Words
ginkgo biloba extract EGB761;fatty liver;hypercholesterolemia |
| Author Name | Affiliation | | MA Dong-ming | The Pathology Department of Tianjin University of TCM, Tianjin 300193, China | | ZHANG Rui-feng | The Pathology Department of Tianjin University of TCM, Tianjin 300193, China | | WANG Qiang | The Pathology Department of Tianjin University of TCM, Tianjin 300193, China | | 郭茂娟 | The Pathology Department of Tianjin University of TCM, Tianjin 300193, China | | 姜希娟 | The Pathology Department of Tianjin University of TCM, Tianjin 300193, China |
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| Abstract
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| [Objective] To observe the effect of Ginkgo biloba extract EGB761 on liver weight and morphology in hypercholesterolemia rabbits. [Methods] The hypercholesterolemia in rabbit was induced by refer to D. Larry Sparks’methods. EGB761 was used to treat the rabbits at a dose of 50mg/kg/d and simvastatin, 5mg/kg/d, as a positive control drug. The index of liver and body was evaluated and the morphological changes of the liver were observed. [Results] Ginkgo biloba extract EGB761 could effectively reduce the liver body index (P<0.01) without significant difference compared to the effect of positive drug simvastatin (P>0.05). General and the microscope morphological observations found that EGB761 could effectively change the general form of fatty degeneration of the liver and histological patterns. [Conclusion] Ginkgo biloba extract EGB761 can effectively prevent and treat fatty liver induced by hypercholesterolemia. |
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