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| Preparation of ligustrazine solid lipid nanoparticles by film-ultrasonic wave dissolving techniques |
| Hits 2283 Download times 2203 Received:April 30, 2009 |
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| DOI
10.11656/j.issn.1672-1519.2009.06.26 |
| Key Words
ligustrazine solid lipid nanoparticles;film ultrasonic wave dissolving technique;preparation |
| Author Name | Affiliation | | RAO Wei-bing | 天津中医药大学 天津 300193 | | HAO Cun-jiang | Tianjin University of TCM, Tianjin Key Laboratory of Chemistry and Analysis of Chinese Materia Medica, Tianjin 300193, China | | WEI Li | Tianjin University of TCM, Tianjin Key Laboratory of Chemistry and Analysis of Chinese Materia Medica, Tianjin 300193, China | | 李发萍 | Tianjin University of TCM, Tianjin Key Laboratory of Chemistry and Analysis of Chinese Materia Medica, Tianjin 300193, China |
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| Abstract
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| [Objective] To prepare the ligustrazine solid lipid nanoparticles and investigate its entrapment efficiency and drug loading. [Methods] The ligustrazine solid lipid nanoparticles were prepared by film ultrasonic wave dissolving techniques. The optimum formula was selected through orthogonal design test according to the entrapment efficiency. [Results] The optimizing technique was using ligustrazine (30 mg),stearic acid (300 mg),lecithin (300 mg),mannitol (30g/L,15 mL). [Conclusion] The preparation technology of ligustrazine solid lipid nanoparticles by film ultrasonic wave dissolving technique is feasible. |
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