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| The influence of acupuncture on IL-8 in brain and serum of the rats with focal cerebral ischemia |
| Hits 1590 Download times 2097 Received:October 11, 2009 |
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| DOI
10.11656/j.issn.1672-1519.2010.01.13 |
| Key Words
acupuncture;cerebral ischemia;IL-8 |
| Author Name | Affiliation | | GUO Yong-ming | Tianjin University of TCM, Tianjin 300193, China | | LIANG Xian-ru | The Affiliated Hospital of Armed Police Medical College, Tianjin 300261, China |
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| Abstract
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| [Objective] To observe the influence of acupuncture on the content of IL-8 in brain and serum of the rats with focal cerebral ischemia.[Methods] One lateral of the middle cerebral artery was obstructed with the thermocoagulation method to induce focal cerebral ischemia.The content of IL-8 in the brain and serum was measured with radio-immunologic method.[Results] Compared with the sham operation group and the normal group,the content of IL-8 in the brain and serum increased significantly at each time point after ischemia in the model group (P<0.05,P<0.01).Compared with the model group,IL-8 was decreased significantly in the acupuncture group in brain at 6,12,24 and 48 hours (P<0.01) and in serum at 6,12 and 48 hours (P<0.05,P<0.01) after acupuncture treatment.[Conclusion] Acupuncture may protect the brain through inhibiting synthesis and secretion of IL-8 in the ischemic tissue regulating the content of IL-8 in serum and inhibiting adhesion and infiltration of inflammatory cells. |
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