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| Establishment of rat model of chronic obstructive pulmonary disease with stagnated phlegm obstructing lung |
| Hits 1645 Download times 1744 Received:October 12, 2009 |
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| DOI
10.11656/j.issn.1672-1519.2010.01.22 |
| Key Words
COPD;stagnated phlegm obstructing lung;the rat model |
| Author Name | Affiliation | | LI Ze-geng | The First Affiliated Hospital of Anhui College of TCM, Hefei 230031, China | | WANG Chuan-bo | The First Affiliated Hospital of Anhui College of TCM, Hefei 230031, China | | PENG Bo | The First Affiliated Hospital of Anhui College of TCM, Hefei 230031, China | | 童佳兵 | The First Affiliated Hospital of Anhui College of TCM, Hefei 230031, China | | 杨程 | The First Affiliated Hospital of Anhui College of TCM, Hefei 230031, China | | 张四春 | The First Affiliated Hospital of Anhui College of TCM, Hefei 230031, China |
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| Abstract
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| [Objective] To establish the rat model of chronic obstructive pulmonary disease (COPD) with stagnated phlegm obstructing lung by combining the disease and symptoms.[Methods] The COPD with stagnated phlegm obstructing lung was established in rats with compelled swimming,exploding in the circumstances of smoke and hypoxia for 4 weeks.The pulmonary function,pulmonary arterial pressure,blood rheology and the pathological changes of the rats’ lung and heart were observed.[Results] The symptoms,pulmonary function,pulmonary arterial pressure,blood rheology and the pathological changes in the lung and heart in the model rats were coincident with COPD with stagnated phlegm obstructing.[Conclusion] This study has established a model of COPD with stagnated phlegm obstructing lung based on the principles of Chinese and Western medicine.This method is feasible and easy to be duplicated in a short period of time and compatible in the clinical practice. |
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