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| Mechanisms of JQF prescription on experimental dysmenorrhea in rats |
| Hits 1804 Download times 1801 Received:November 20, 2009 |
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| DOI
10.11656/j.issn.1672-1519.2010.01.23 |
| Key Words
JQF;dysmenorrhea;prostaglandin;hormone |
| Author Name | Affiliation | | FANG Ling | Tianjin University of TCM, Tianjin 300193, China | | ZHU Xin-bing | Tianjin University of TCM, Tianjin 300193, China | | YIN Ju | Tianjin Central Hospital of Obstetrics and Gynecology, Tianjin 300193, China | | 郭虹 | Tianjin University of TCM, Tianjin 300193, China | | 高岚 | Tianjin University of TCM, Tianjin 300193, China | | 张艳军 | Tianjin University of TCM, Tianjin 300193, China |
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| Abstract
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| [Objective] To investigate the effect and mechanism of JQF (analgesic prescription used before menorrhea) in regulating prostaglandin,estrogen and endocrine in the rats with dysmenorrhea.[Methods] Rats with dysmenorrhea were induced and different dose of JQF were given to each group and aspirin was used as the control medicine.The changes of PGF2α,PGE2,TXB2,6-keto-PGF1α,estrin and progestogen in the tissue of uterus were observed by radioimmunity assay.[Results] Compared to the control group,PGE2 and progestogen were increased significantly,and PGF2α,PGF2α/PGE2,TXB2,TXB2/6-keto-PGF1α and estrin decreased in the group with high dose JQF (P<0.01).[Conclusion] JQF was effective in regulating prostaglandin,estrin and progestogen in uterus of rats with dysmenorrhea.JQF was helpful for restraining the contraction of smooth muscle in uterus and reducing the tension of the muscle,which could be the mechanisms of JQF. |
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