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| Effect of Xufu Daizhe decoction on CyclinD1 expression in mixed reflux esophagitis in rat |
| Hits 1694 Download times 2008 Received:December 07, 2009 |
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| DOI
10.11656/j.issn.1672-1519.2010.01.25 |
| Key Words
Xufu Daizhe decoction;mixed reflux esophagitis;Cyclin D1;experimental study |
| Author Name | Affiliation | | YANG You-xin | International Education College, Tianjin University of TCM, Tianjin 300193, China | | YUAN Hong-xia | Tianjin University of TCM, Tianjin 300193, China | | MA Yan | Tianjin University of TCM, Tianjin 300193, China | | 韩顺平 | International Education College, Tianjin University of TCM, Tianjin 300193, China | | 魏爱勤 | Nankai TCM Hospital, Tianjin 300400, China | | 潘淼 | International Education College, Tianjin University of TCM, Tianjin 300193, China | | 徐军娟 | Tianjin University of TCM, Tianjin 300193, China |
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| Abstract
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| [Objective] To observe the effect of Xuanfu Daizhe decoction on the expression of cyclin D1 in the esophageal mucosa in rat with mixed reflux esophagitis.[Methods] Eighty Wistar rats were randomly divided into normal control group, model group, Chinese medicine treatment group and Western medicine control group. The operation of end-to-side anastomosis of the esophagus and duodenum was performed for all groups except the normal control group. Normal saline, Xufu Daizhe decoction and suspension liquid of citrate mosapride dispersible tablets were given continuously for 21 days from the second week after the operation. The expression of Cyclin D1 in esophageal mucosa was observed.[Results] The expression of Cyclin D1 was significantly increased in the model group compared with the normal control group. Compared with the model group, the expression of Cyclin D1 decreased significantly in both Chinese medicine group and Western medicine control group, and the decrease was more in the Chinese medicine group. No significant difference was found on the expression of Cyclin D1 between Chinese medicine group and normal control group.[Conclusion] Xuanfu Daizhe decoction can significantly decrease the expression of Cyclin D1 in esophageal mucosa and so can be effective for treating the mixed reflux esophagitis. |
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