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| Effect of light on stability of cholerythrin and content of cholerythrin in the Guipu Shenqing tablet |
| Hits 2186 Download times 2124 Received:October 21, 2009 |
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| DOI
10.11656/j.issn.1672-1519.2010.01.32 |
| Key Words
HPLC;cholerythrin;stability |
| Author Name | Affiliation | | ZHANG Dong-fang | Pharmaceutical Science College, Chinese Medical University, Shenyang 110001, China | | ZHOU Mei-huan | Shenyang North-east DaYaoFang Corporate Chain, Shenyang 110023, China | | YUAN Chang-ji | Pharmaceutical Science College, Chinese Medical University, Shenyang 110001, China |
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| Abstract
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| [Objective] To investigate the stability of cholerythrin and measure its content in the Guipu Shenqing tablet.[Methods] Cholerythrin was determined by HPLC.The amount of cholerythrin before and after the explosion of sunlight was compared by HPLC and UV spectrum.[Results] Cholerythrin was not stable and its peak area decreases for 1.6% in half an hour without light.It showed that the precision (RSD=1.2%),reproducibility (RSD=2.0%) and recovery rate could reach the need of experiments.Cholerythrin was sensitive to sunlight.It completely vanishes in sunlight for 3 hours and no cholerythrin was found by HPLC.[Conclusion] HPLC could be used to measure the content of cholerythrin and the drug should be prepared quickly with no light. |
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