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| Preparation of the core with 5-Aminosalicylic acid in pellet of colon-specific delivery system |
| Hits 1806 Download times 1535 Received:September 28, 2009 |
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| DOI
10.11656/j.issn.1672-1519.2010.01.33 |
| Key Words
extrusion-spheronization;pellet;colon-specific delivery system |
| Author Name | Affiliation | | CHEN Yu-zhou | Chinese Materia Medica College, Tianjin 300193, China | | WANG Dong-kai | College of Pharmacy, ShenYang Pharmaceutial University, Shenyang 110016, China | | TIAN Ding-xia | Xunxian People’s Hospital, Henan 456250, China | | 王新建 | Xunxian People’s Hospital, Henan 456250, China | | 时念秋 | 山东轻工业学院制药工程学院, 济南, 250353 |
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| Abstract
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| [Objective] To prepare the cores in pellets for colon inflammatory disease with 5-aminosalicylic acid.[Methods] The maximum drug load of the pellet cores was studied.The effect of CMS-Na on the speed of dissolution was observed,and the effects of ethanol on hardness,the speed of dissolution and the friability of the cores were also observed.[Results] The maximum drug load of the pellet was 75%(w/w).The maximum of CMS-Na was 4%(w/w) and the more the CMS-Na was contained the fast the dissolution was.Increased ethanol was helpful in improving the hardness and friability of cores and in decreasing the time of dissolution.The weight ratio of solid powder to water should be kept around 1.6 to guarantee the process of extrusion.[Conclusion] With the prescription and parameters of this study,the produced cores are smooth,hard and round enough to be coated in the following step. |
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