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| Effects of Xinfeng capsule in treating ankylosing spondylitis and dysphoric depression |
| Hits 1588 Download times 2022 Received:November 20, 2009 |
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| DOI
10.11656/j.issn.1672-1519.2010.02.03 |
| Key Words
ankylosing spondylitis;anxiety and depression;XinFeng capsule;clinical efficacy |
| Author Name | Affiliation | | LIU Jian | Rheumatism Department, The First Affiliated Hospital of Anhui College of TCM, Hefei 230031, China | | SHENG Chang-jian | Rheumatism Department, The First Affiliated Hospital of Anhui College of TCM, Hefei 230031, China | | XIE Xiu-li | Rheumatism Department, The First Affiliated Hospital of Anhui College of TCM, Hefei 230031, China | | 万磊 | Rheumatism Department, The First Affiliated Hospital of Anhui College of TCM, Hefei 230031, China |
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| Abstract
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| [Objective] To observe the clinical efficacy of Xinfeng capsule (XFC) and the effect on anxiety and depression and ankylosing spondylitis (AS). [Methods] The grade score was obtained by using anxiety self-rating scale (SAS),depression self-rating scale (SDS),pain visual analogue method (VAS method),functional index (BASFI),disease activity index (BASDAI),the overall index (BAS-G),the symp-toms rating scale,etc. Sixty patients of AS were randomly divided into treatment group and control group. Forty patients of treatment group were treated with Xinfeng capsule (XFC),twenty patients of control group with sulfasalazine (SASP). The curative effect of main symptoms and signs,anxiety and depression,erythrocyte sedimentation rate (ESR),C-reactive protein (CRP),etc. were measured. [Results] The standard criteria of curative effect was ASAS20 and BASDAI50. The curative effect of XFC group was 75%,70% and that of SASP group was 20%,10%. The curative effect of XFC group was superior to that of SASP (P<0.01 or P<0.05). The SAS and SDS scores were 42.03±8.40,53.80±9.64 vs 41.38±9.16,52.70±6.88 in both groups. The scores of XFC group was superior to that of SASP (P<0.01 or P<0.05). The level of VAS,symptoms and signs,ESR,CRP,BASDAI,BASFI,BAS-G and BASMI in the XFC and SASP group was evaluated. There was a significant difference before and after treatment of XFC and SASP group (P<0.01 or P<0.05). [Conclusion] Clinical effect of XFC group was superior to that of SASP group. It is suggested that XFC may significantly lower SAS,SDS integral,improve clinical symptoms in pa-tients with AS and the related indicators. |
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