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| Relationship between insulin sensitivity,insulin-like growth factor binding protein-1 and TCM syndrome differentiation in patients with dementia |
| Hits 1571 Download times 1588 Received:October 27, 2009 |
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| DOI
10.11656/j.issn.1672-1519.2010.02.08 |
| Key Words
insulin sensitivity;insulin-like growth factor binding protein-1;dementia;differentiation of symptoms and signs for classification of syndrome;clinical study |
| Author Name | Affiliation | | LIU Ying-lu | Nanjing University of Chinese Medicine, Nanjing 210046, China | | ZHANG Hong | The Affiliated Gulou Hospital of Medical College of Nanjing University, Nanjing 210008, China |
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| Abstract
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| [Objective] To investigate the relationship and significance between insulin sensitivity,insulin-like growth factor binding protein-1 (IGFBP-1) and traditional Chinese medicine syndrome differentiation of dementia. [Methods] Syndromes of 50 patients were divided into two types:asthenia of both the spleen and kidney and deficiency of vital energy and stagnation of blood. The serum fasting insulin (FINS) and IGFBP-1 of dementia group and normal group were detected. The insulin resistance index (IAI) was calculated. [Results] There was no difference in the level of FBG among three groups (P>0.05). The level of FINS and IGFBP-1 increased in group with asthenia of both the spleen and kidney and with deficiency of vital energy and stagnation of blood group compared with the normal groups,hav-ing significantly differences (P<0.01),and there was differences in patients of two groups (P<0.01,P<0.05). Compared with the normal group,the level of IAI in group with asthenia of both the spleen and kidney and deficiency of vital energy and stagnation of blood group decreased. There was difference between three groups (P<0.05). Pearson correlation analysis showed that IGFBP-1 was correlated with FBG,FINS and IAI. Among them,IGFBP-1 was positively correlated with FBG and FINS,and negatively correlated with IAI. [Conclusion] The abnormal level of serum insulin is the important factor in the development of dementia. The asthenia of both the spleen and kidney was the major pathogenic factor in dementia. |
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