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Study on serum active constituents of Shuanghuanglian dry cryogen powder in rats
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DOI   10.11656/j.issn.1672-1519.2010.02.36
Key Words   Shuanghuanglian Powder-Injection;elemental pharmacodynamic compound;HPLC finger print;serum pharmacochemistry
Author NameAffiliation
GUO Jie Gynecology of the Second Hospital Affiliated to Tianjin University of TCM, Tianjin 300150, China 
SONG Dian-rong Gynecology of the Second Hospital Affiliated to Tianjin University of TCM, Tianjin 300150, China 
WANG Yue-fei Gynecology of the Second Hospital Affiliated to Tianjin University of TCM, Tianjin 300150, China 
王跃飞 The Traditional Chinese Medicine Research Centre of Tianjin University of TCM, key Laboratory of Pharmacology of Formulae, Ministry of Education, Tianjin 300193, China 
徐燕颖 Gynecology of the Second Hospital Affiliated to Tianjin University of TCM, Tianjin 300150, China 
潘桂湘 The Traditional Chinese Medicine Research Centre of Tianjin University of TCM, key Laboratory of Pharmacology of Formulae, Ministry of Education, Tianjin 300193, China 
Abstract
    [Objective] To investigate the active compounds in Shuanghuanglian Powder Injection (SHL) It was determined by serum phar-macochemistry for illuminating the elemental pharmacodynamic compounds and providing the foundation for optimizing the prescription of SHL. [Methods] Plasma was obtained from Wistar rats 10 min,12 h after intravenous injection of SHL. Based upon the established HPLC fingerprint of SHL,it was compared with HPLC fingerprints of blank serum,serum containing drug and SHL. The serum active compounds in SHL were analyzed. [Results] Twenty-one compounds were separated by HPLC,seven compounds were confirmed to be the SHL respectively as follow:caffeotannic acid,forsythoside,baicalin,forsythin,luteolin,wogonoside and baicalein; seventeen com-pounds contained in SHL were determined in the rats serum after being administrated with SHL for 10 min. Baicalin,luteolin,wogonoside and a unknown compound were determined in the serum after being administrated with SHL for 12 h. [Conclusion] The seven compounds of SHL maybe the main active compounds and the elemental pharmacodynamic compounds of SHL,Baicalin,luteolin,and wogonoside had an important effect in maintaining the curative effect of SHL.

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