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| Effect of"Sitian Points"acupuncture on expression of peripheral inflammatory factors mRNA in unbalanced cervical spondylopathy between dynamic and static stress in rats |
| Hits 1825 Download times 1622 Received:March 02, 2010 |
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| DOI
10.11656/j.issn.1672-1519.2010.04.06 |
| Key Words
Sitian Points;cervical spondylopathy;IL-1βmRNA;iNOS mRNA;RT-PCR method |
| Author Name | Affiliation | | ZHOU Zhen | The Second Affiliated Hospital of Tianjin University of TCM, Tianjin 300150, China | | WANG Zun-lai | Tianjin North Gate Hospital, Beichen District, Tianjin 300400, China | | WANG Xiu-yun | Tianjin University of TCM, Tianjin 300193, China | | 孟向文 | Tianjin University of TCM, Tianjin 300193, China | | 尚秀葵 | Tianjin University of TCM, Tianjin 300193, China |
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| Abstract
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| [Objective] To observe the effect of Sitian points acupuncture on the expression of the peripheral inflammatory factors in dynamic and static stress unbalanced cervical spondylopathy rats,and to discuss the interaction mechanisms of intervertebral disc degeneration in cervical spondylopathy rats. [Methods] Sixty Wister rats were used.They were randomly divided into 4 groups(sham operation group,model group,Acupuncture on Sitian Points group,Acupuncture on Jiaji Points group),and the dynamic and static stress unbalanced cervical spondylopathy models were established.We punctured Sitian points and Jiaji points respectively,and at 1st,2nd and 4th week after establishing the model we detected the expression of IL-1β mRNA,iNOS mRNA in model rats’ cervical disc,which were punctured with Sitian points,by RT-PCR method. [Results] Acupuncture on Sitian points could markedly reduce the expression of the peripheral inflammatory factors(IL-1β mRNA,iNOS mRNA) in intervertebral disc. [Conclusion] Acupuncture on Sitian points could decrease intervertebral disc degeneration,and the mechanism might be related with inhibiting the expression of IL-1β mRNA and iNOS mRNA. |
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