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| A systematic evaluation on Xianlinggubao capsule for postmenopausal osteoporosis |
| Hits 1677 Download times 2216 Received:June 20, 2010 |
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| DOI
10.11656/j.issn.1672-1519.2010.04.07 |
| Key Words
Xianlinggubao capsule;postmenopausal osteoporosis;systematic review |
| Author Name | Affiliation | | ZHAO Yi-jun | China Academy of Chinese Medical Science, Beijing 100700, China | | HU Jing | Tianjin University of TCM, Tianjin 300193, China | | CHEN Jing | Tianjin University of TCM, Tianjin 300193, China | | 商洪才 | Tianjin University of TCM, Tianjin 300193, China |
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| Abstract
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| [Objective] To assess the efficacy and safety of Xianling Gubao Capsule(XLGB) in treating postmenopausal osteoporosis(PMOP). [Methods] All data of the clinical trials of XLGB for postmenopausal osteoporosis were searched from Cochrane library,PubMed,EMbase,CBM,CNKI and VIP.To evaluate the methodological quality of included studies,the RevMan 5.0 was used for data analysis. [Results] A total of 7 trials were included,only 3 trials used random number table.The improvement of L2-L4 bone mineral density(BMD),femoral neck BMD,Ward’s triangle BMD and femoral greater trochanter BMD on 3 months in XLGB group were better than calcium group,the improvement of Ward’s triangle BMD and femoral greater trochanter BMD on 6 months in XLGB group were better than calcium group,the improvement of serum oestradiol on 6 and 12 months in XLGB group was better than calcium group.The improvement of serum oestradiol on 6 and 12 months in Western medicine group was better than XLGB group.The improvement of L2-L4 BMD and femoral neck BMD on 6 months in XLGB plus Western medicine group was better than Western medicine group.No significant adverse drug reactions of XLGB were reported. [Conclusion] The evidence currently available showed that XLGB may improve BMD and serum oestradiol compared with calcium group.However,because of the small sample of included trials,the conclusions need to be interpreted cautiously,and more well-designed,high-quality RCTs need to be performed. |
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