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| Clinical research on early effect of Gulening capsule in promoting fracture healing |
| Hits 1726 Download times 1567 Received:February 08, 2010 |
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| DOI
10.11656/j.issn.1672-1519.2010.04.09 |
| Key Words
traditional Chinese medicine;fracture healing;VEGF |
| Author Name | Affiliation | | REN Shou-ping | The Beichen TCM Hospital Affiliated to Tianjin University of TCM, Tianjin 300400, China | | JIN Hong-bin | The Trauma Center of Tianjin Hospital, Tianjin 300211, China |
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| Abstract
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| [Objective] To observe the effect of tonifying qi and blood and promoting blood flow method in the course of fracture healing and explore the effect mechanism of promoting fracture healing by analyzing serum index and bony callus growth in the patients of early bone fracture. [Methods] Forty-two patients of bone fracture were randomly divided into treatment group(A:tonifying qi and blood and promoting blood flow) and control group(B:promoting blood flow and eliminating stagnant blood).The change of symptoms and stagnant blood before and after treatment were observed.The peripheral blood VEGF,BAP level were determined with ELISA and the bony callus growth condition was evaluated with X-ray examination. [Results] The serum VEGF and BAP of treatment group was obviously higher than that of control group in seven days(P<0.05).Compared to B group,there was a increasing tendency in the VEGF level of treatment group. [Conclusion] The Gulening capsule may increase the activity of osteoplast,promote the synthesis and release of VEGF and BAP and may effectively increase the union of fracture in early fracture healing.The curative effect of Gulening capsule has a more obvious advantage than that of simple promoting blood flow and eliminating stagnant blood group. |
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