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| Influence of Huazhuotongmai Powder on TXB2,ET in rabbits with ASO |
| Hits 1495 Download times 1624 Received:May 20, 2010 |
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| DOI
10.11656/j.issn.1672-1519.2010.04.24 |
| Key Words
Huazhuo Tongmai Powder;Arteriosclerosis obliterans;TXB2;ET |
| Author Name | Affiliation | | LI Shen-xian | The Affiliated Shengjing Hospital of Chinese Medical University, Shenyang 110004, China | | WU Hong-lei | The Affiliated Shengjing Hospital of Chinese Medical University, Shenyang 110004, China |
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| Abstract
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| [Objective] To study the mechanism of Huazhuo Tongmai Powder in treating rabbit with ASO and explore its effect mechanism. [Methods] Forty New Zealand rabbits were fed with high fat diet and given femoral artery balloon injury to establish the ASO model.They were randomly divided into 4 groups:Huazhuo Tongmai Powder group(A),Aspirin group(B),High fat diet group(C) and sham surgery group(D).The level of NO,ET,6-Keto-PGF1α and TXB2 after drug intervention was determined.At the end of the experiment the part of vascular endothelial cells was observed with High-power transmission electron microscopy. [Results] Huazhuo Tongmai Powder could decrease the level of TXB2,ET(P<0.01) and increase NO,6-Keto-PGF1α(P<0.01).The damaged fat cells in vessels were significantly reduced. [Conclusion] Huazhuo Tongmai Powder could protect the arterial intima and treat arteriosclerosis obliterans. |
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