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| Effect of Biqi capsule on the cartilaginous tissue of knee joints in rats with osteoarthritic |
| Hits 1714 Download times 1949 Received:March 20, 2010 |
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| DOI
10.11656/j.issn.1672-1519.2010.04.25 |
| Key Words
Biqi capsule;osteoarthritis;pathological changes |
| Author Name | Affiliation | | LIU Zhan-biao | Research Institute of TCM, Tianjin University of TCM, Tianjin 300193, China | | SHI Yong-mei | Research Institute of TCM, Tianjin University of TCM, Tianjin 300193, China | | XU Fang | Research Institute of TCM, Tianjin University of TCM, Tianjin 300193, China | | 史红 | Research Institute of TCM, Tianjin University of TCM, Tianjin 300193, China | | 张少卓 | Research Institute of TCM, Tianjin University of TCM, Tianjin 300193, China | | 胡利民 | Research Institute of TCM, Tianjin University of TCM, Tianjin 300193, China |
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| Abstract
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| [Objective] To observe the effect of Biqi Capsule on the cartilage histopathologic changes of knee joints in rats with osteoarthritic. [Methods] In Wistar rats,papain was injected into their knee joints to establish the animal model of Osteoarthritis.They were treated with Biqi Capsule(HDG 1.296 g/kg,MDG 0.648 g/kg,LDG 0.324 g/kg) through intragastric administration for six weeks.The cartilage histopathology of knee joint was observed in rat with osteoarthritis. [Results] The extent of edema,degeneration,cluster-like proliferation and necrosis of cartilaginous tissue in treated groups was smaller than those in model group.The accumulated pathology grades of the three treated groups was 41.5,13.5,19 scores respectively.They were lower than that of model groups,which was 57.5 score.The necrosis incidence of chondrocyte in treated groups was 64.%,30%,30% respectively,while it was 70% in model groups.The accumulated pathology grades of the three treated groups were 12.5,6.5,3.5 scores respectively,while it was 29 in the model group,By rank sum test,there was a significant deviation between treated groups(MDG 0.648 g/kg,LDG 0.324 g/kg) and model group(P<0.01). [Conclusion] Biqi Capsule has a protective effect against necrosis of cartilaginous tissue of knee in rats with osteoarthritis. |
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