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| Anti-inflammatory effect of spraying agent for nasal healing |
| Hits 1439 Download times 1760 Received:March 31, 2010 |
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| DOI
10.11656/j.issn.1672-1519.2010.04.31 |
| Key Words
Nasal Healing Spraying Agent(NHSA);the model of auricular swelling reaction in mice;the rat paw edema model reaction;the Cotton Ball Granuloma reaction in rat;anti-inflammatory |
| Author Name | Affiliation | | WANG Jing-juan | Beijing University of Chinese Medicine, Beijing 100102, China | | ZHANG Gui-jun | Beijing University of Chinese Medicine, Beijing 100102, China | | YANG Shu | Beijing University of Chinese Medicine, Beijing 100102, China |
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| Abstract
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| [Objective] To study the anti-inflammatory effect of Nasal Healing Spraying Agent(NHSA). [Methods] We used the model of auricular swelling reaction in mice,the rat paw edema model reaction,and the Cotton Ball Granuloma reaction in rat.The animals were designed into blank and positive control groups. [Results] The degree of swelling of mice auricle of blank control group was 12.05±1.52 mg;The degrees of the high dose group,middle dose group,low dose group were 3.42±3.32 mg,5.95±2.04 mg,10.30±1.75 mg respectively,and were significant in statistic analysis(P<0.05 or P<0.01);The rate of the right postal toes and ankle swelling of rat of the high dose group,middle dose group,low dose group were remarkably decreased 2 h after making inflammation,while the most significant was found at 4～6 h.They were statistically significant difference(P<0.05 or P<0.01) compared with the blank control group;The weight of granuloma in rats from the blank control group was 224.99 ±83.09 mg/100g weight;The weights of the high dose group,middle dose group,low dose group are 144.61±25.82 mg/100 g body weight,163.78±21.49 mg/100 g b.w.,210.42±69.60 mg/100 g b.w.respectively,and were significant statistically(P<0.05). [Conclusion] NHSA could abate the degree of swelling of mice auricle and had anti-inflammatory effect.It could abate the rate of the right postal toes and ankle swelling of rat and had anti-inflammatory effect.It could inhibit the formation of cotton ball granuloma in rats and had anti-inflammatory effect.NHSA had immunoregulatory function. |
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