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| Reverse effect of multiple drug-resistance of A549/DDP by Xiaoyan Tang-containing serum |
| Hits 1794 Download times 1599 Received:May 21, 2010 |
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| DOI
10.11656/j.issn.1672-1519.2010.04.33 |
| Key Words
Chinese herbs;blood serum pharmacology;lung cancer;A549/DDP cell;drug resistance |
| Author Name | Affiliation | | ZHANG Ying | The First Hospital Affiliated to Tianjin University of TCM, Tianjin 300193, China | | JIA Ying-jie | The First Hospital Affiliated to Tianjin University of TCM, Tianjin 300193, China | | YANG Jie | Tianjin University of TCM, Tianjin 300193, China | | 李小江 | The First Hospital Affiliated to Tianjin University of TCM, Tianjin 300193, China |
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| Abstract
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| [Objective] To study the effects of Xiaoyan Tang-containing serum on the inhibition of tumor growth in KM mice and the reverse effect of multiple drug-resistance of A549/DDP Cells. [Methods] The inhibitory effect of Xiaoyan Tang on the tumor growth of S180 transplanted KM in mice was studied.Taking the lung cancer sensitive cell A549 and the drug-resistant cell A549/DDP in research to observe the cell toxicity of Xiaoyan Tang-containing serum to the A549 and A549/DDP and the influence on the reversion of multiple drug-resistance effect to DDP,determined by MTT assay method. [Results] The tumor-inhibiting rate of Xiaoyan Tang with high and low dose group was 48.36% and 27.87%.In tumor-bearing animals Xiaoyan Tang-containing serum with high or low dose combined with DDP the cell killing effect on A549/DDP was 1.78 times and 1.57 times more than DDP group. [Conclusion] Xiaoyan Tang can improve the life quality of mice,suppress the growth of the transplanted tumor,prevent cachexia caused by tumor.Xiaoyan Tang-containing serum can inhibit A549 cells and A549/DDP cells from proliferation.It can enhance the lethal effect of DDP on the sensitive cell or drug-resistant cell,having reverse effect on multiple drug-resistance. |
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