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| The influence of SPS on the proliferation of PBMC in vitro and cytokines secretion |
| Hits 1521 Download times 2179 Received:February 03, 2010 |
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| DOI
10.11656/j.issn.1672-1519.2010.04.34 |
| Key Words
Safflower polysaccharide(SPS);Peripheral blood mononuclear cells(PBMC);proliferation;IL-2;TNF-α;IFN-γ |
| Author Name | Affiliation | | SHI Xue-kui | Teaching and Research Section of Pathogenic Biology, Mudanjiang Medical College, Mudanjiang 157011, China | | RUAN Dian-qing | Mulan center for disease control and prevention, Harbin 151900, China | | TAO Ji | Department of Microbiology and Immunology, Heilongjiang University of Traditional Chinese Medicine, Harbin 150040, China | | 周明瑶 | Department of Microbiology and Immunology, Heilongjiang University of Traditional Chinese Medicine, Harbin 150040, China | | 王亚贤 | Department of Microbiology and Immunology, Heilongjiang University of Traditional Chinese Medicine, Harbin 150040, China |
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| Abstract
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| [Objection] To discuss the influence of SPS on the proliferation of PBMC in vitro and Cytokines secretion. [Methods] PBMC from healthy donors were incubated with different doses of SPS in vitro.The proliferative activity of PBMC and serum IL-2,TNF-α,IFN-γ were measured. [Results] SPS(1.25 g/L and 0.625 g/L dose group) could obviously stimulate the proliferation of PBMC(P<0.05);The level of IL-2,IFN-γ of SPS were dramaticlly higher than those in conrtrol group.(P<0.05).There was no significant difference in TNF-α-concentration in each group. [Conclusion] SPS can promote the proliferation of PBMC and can enhance IL-2 and IFN-γ levels and im-mune function. |
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