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| Effects of Naokang Ⅱ on concentration of methylglyoxal in serum of rats with diabetes |
| Hits 1511 Download times 1531 Received:April 10, 2010 |
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| DOI
10.11656/j.issn.1672-1519.2010.05.04 |
| Key Words
Naokang Ⅱ;methylglyoxal;diabetes;gas chromatography-mass spectrometry(GC-MS) |
| Author Name | Affiliation | | CHEN Yu-jing | Department of TCM, Xuanwu Hospital of Capital Medical University, Beijing 100053, China | | HUANG Xiao-bo | Department of TCM, Xuanwu Hospital of Capital Medical University, Beijing 100053, China | | LI Zong-xin | Department of TCM, Xuanwu Hospital of Capital Medical University, Beijing 100053, China | | 刘洋 | 北京市理化分析测试中心, 北京, 100089 | | 陈文强 | Department of TCM, Xuanwu Hospital of Capital Medical University, Beijing 100053, China | | 李林 | 北京市理化分析测试中心, 北京, 100089 |
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| Abstract
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| [Objective] To observe the effect of Naokang Ⅱ on the concentration of methylglyoxal(MG) in serum of diabetic rats in order to provide the theoretical basis for its clinic application in treating cognitive dysfunction in diabetic patients.[Methods] The diabetes mellitus(DM) was produced in rats by intraperitoneal injection of streptozotocin and feeding with high fat food and sucrose diet.The Naokang II-treated rats were given different doses of Naokang Ⅱ per oral,whereas the control and DM model groups were given double distilled water for 4 consecutive weeks.Gas Chromatography-Mass Spectrometry(GC-MS) was applied to determine the concentration of methylglyoxal(MG) in serum of rats.[Results] The concentration levels of MG in diabetic rats(216.67±15.56) μg/L was significantly high-er than that in the control group(85.29±24.97) μg/L.Different doses of Naokang Ⅱ could restore the level of MG to(178.8±19.34) μg/L,(137.9±16.95)μg/L and(128.47±16.77) μg/L,respectively.[Conclusion] Naokang Ⅱ can down-regulate the level of MG in serum of diabetic rats,and this effect may be one of the mechanisms in treating diabetic cognitive dysfunction. |
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