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| Effect of Weiwei prescription on activity of MPO and H+-K+-ATPase of gastric mucosa in rats with experimental gastric ulcer |
| Hits 1789 Download times 1831 Received:April 10, 2010 |
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| DOI
10.11656/j.issn.1672-1519.2010.05.25 |
| Key Words
Weiweifang;gastric ulcer;MPO;H+-K+-ATPase |
| Author Name | Affiliation | | ZHANG Zhen-rui | The TCM Diagnostics Department of Traditional Chinese Medicine College, Southern Medical University, Guangzhou 510515, China | | LIU Xiao-wei | The TCM Diagnostics Department of Traditional Chinese Medicine College, Southern Medical University, Guangzhou 510515, China | | PENG Shu-ling | The TCM Diagnostics Department of Traditional Chinese Medicine College, Southern Medical University, Guangzhou 510515, China | | 杨健 | The TCM Diagnostics Department of Traditional Chinese Medicine College, Southern Medical University, Guangzhou 510515, China |
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| Abstract
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| [Objective] To investigate the effect of Weiweifang(WWF) on the activity of MPO and H+-K+-ATPase of gastric mucosa in rat with experimental gastric ulcer and to explore the possible mechanism of WWF in repairing stomach mucosa damage.[Methods] The model was induced by acetic acid and colorimetric method was used to determine the activity of MPO and H+-K+-ATPase in gastric mu-cosa.Meantime,the pathologic change of gastric mocosa was examined.[Results] The therapeutic effect of middle dose WWF group was the best on observing the gastric mucosa and tissue slice.Comparison of results among self-cure group,model group and experimental group found that WWF could inhibit MPO activity significantly(P<0.01 or P<0.05),especially in mid-dose group.The activity of H+-K+-ATPase could be raised by WWF because its activity were higher in cured groups of WWF than those in self-cure group(P<0.01 or P< 0.05) and similar to that of the normal group.[Conclusion] WWF could exert a significant protective effect against experimental gastric ulcer,possibly by decreasing MPO activity and ameliorating the gastric mucosa damage of inflammatory mediators,meanwhile,it could recover H+-K+-ATPase activity by repairing mucosa damage. |
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