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| Dynamic effects of Fuhuang Shengji Yuchuang Ointment on cell cycle of granulation tissue of wound surface in wister rat with diabetes |
| Hits 1594 Download times 1693 Received:May 20, 2010 |
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| DOI
10.11656/j.issn.1672-1519.2010.05.27 |
| Key Words
Compound Rhubarb Granulation-Promoting and Wound-Healing Ointment;wound healing;cell cycle;traditional Chinese medicine |
| Author Name | Affiliation | | XIAO Xiu-li | Shanghai Baoshan TCM Hospital, Shanghai 201900, China | | WANG Zhen-yi | Shanghai Yueyang Integrated TCM and WM Hospital Affiliated toShanghai University of TCM, Shanghai 200437, China | | TANG Han-jun | Shanghai Longhua Hospital Affiliated to Shanghai University of TCM, Shanghai 200032 |
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| Abstract
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| [Objective] To explorer the dynamic effects of Fuhuang Shengji Yuchuang Ointment(Compound Rhubarb Granulation-Pro-moting and Wound-Healing Ointment,CRGWO) on cell cycle of granulation tissue of Wistar rat with diabetes in wound healing.[Meth-ods]Thirty-six male Wistar rats were randomly divided into three groups: diabetic trial(CRGWO) group,normal control group,diabetic control group.The cell cycle in granulation tissue of the rats were detected with flow cytometry.[Results] On the third day of wound heal-ing,cells in G0-G1 phase and S phase has no statistical difference among three groups.On the eleventh day of wound healing,cells in G0-G1 phase of the rats wound in diabetic trial(CRGWO) group were lower than those of diabetic control group(P<0.05),cells in S phase of the rats wound in diabetic trial(CRGWO) group were higher than those of diabetic control group(P<0.05),but without statistical differ-ence when compared to the normal control group.[Conclusion] CRGWO can stimulate the cells proliferation of diabetic wound,thus ac-celerate the process of wound healing. |
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