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| Effects of EGB761 on antioxidation in rabbits with cholesterol-copper induced alzheimer dementia |
| Hits 1476 Download times 1742 Received:July 20, 2010 |
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| DOI
10.11656/j.issn.1672-1519.2010.05.28 |
| Key Words
EGB761;copper;cholesterol;SOD;MDA;GSH-PX |
| Author Name | Affiliation | | LI Ping | Tianjin University of TCM, Tianjin 300193, China | | ZHANG Rui-feng | 天津中医药大学, 天津, 300193 | | MA Dong-ming | 天津中医药大学, 天津, 300193 | | 姜希娟 | 天津中医药大学, 天津, 300193 | | 苏金玲 | 天津中医药大学, 天津, 300193 | | 卢斌 | 天津中医药大学, 天津, 300193 | | 郭茂娟 | 天津中医药大学, 天津, 300193 |
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| Abstract
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| [Objective] To observe the effects of Ginkgo biloba extract EGB761 on serum SOD,MDA,GSH-PX in rabbits with cholesterol-copper induced Alzheimer dementia.[Methods] The cholesterol-copper induced Alzheimer dementia in rabbit was established by modi-fied D.Larry Sparks’ methods.EGB761 was used to treat the rabbits per oral at a dose of 50 mg(kg·d) for 3 weeks.Then serum MDA con-tent,SOD and GSH-PX activity of rabbit were observed and compared between groups.[Results] MDA content and SOD and GSH-PX activity was obviously increased in rabbit with cholesterol-copper induced Alzheimer dementia with significant difference compared to control group(P<0.05).In EGB761 group MDA content and SOD and GSH-PX activity was obviously declined compared with model group(P<0.05).Compared with control group SOD level in EGB761 group showed decreasing tendency,and GSH-PX levels showed in-creasing trend without any statistical significance.[Conclusion] Obviously peroxidation injury was existed in rabbit with cholesterol-cop-per induced Alzheimer dementia.EGB761 has a certain protective effect against it. |
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