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| Effect of salvianolic acid B on contraction of porcine coronary artery |
| Hits 1568 Download times 1521 Received:June 12, 2010 |
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| DOI
10.11656/j.issn.1672-1519.2010.05.30 |
| Key Words
salvianolic acid B;coronary artery;contraction |
| Author Name | Affiliation | | ZHU Jin-qiang | The TCM Research Institute of Tianjin University of TCM, Tianjin Key Labratory of Chinese Medical Pharmacology, Key Laboratory of Science of TCM Formula by Ministry of Education, Tianjin 300193, China | | JIA Xiao-xu | The TCM Research Institute of Tianjin University of TCM, Tianjin Key Labratory of Chinese Medical Pharmacology, Key Laboratory of Science of TCM Formula by Ministry of Education, Tianjin 300193, China | | KANG Li-yuan | The TCM Research Institute of Tianjin University of TCM, Tianjin Key Labratory of Chinese Medical Pharmacology, Key Laboratory of Science of TCM Formula by Ministry of Education, Tianjin 300193, China |
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| Abstract
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| [Objective] To observe the effect of salvianolic acid B(Sal B) on the contraction of porcine coronary artery strips,and investi-gate its mechanism of action.[Methods] Using experimental method of smooth muscle in vitro the effect of Sal B on the contraction of porcine coronary artery strips induced by KCL,CaCl2 and Hist was observed.[Results] Salvianolic acid B had nonparallel right migration effect on KCl,CaCl2 and Histamine induced dose-response curves,and decrease the maximal effect.Moreover,it can greatly inhibit in-tracellular Ca2+-dependent contraction induced by Histamine,and show relatively little effect on the extracellular Ca2+-dependent contrac-tion induced by CaCl2.[Conclusion] Salvianolic acid B had a significant relaxing effect on contraction of porcine coronary artery,and had an antagonistic effect on the two kinds of contractions. |
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