|
| Influence of acupuncture on IL-6 in ischemic brain tissue and serum in rats with focal cerebral ischemia |
| Hits 1567 Download times 1510 Received:May 20, 2010 |
| View Full Text View/Add Comment Download reader |
| DOI
10.11656/j.issn.1672-1519.2010.06.14 |
| Key Words
acupuncture;cerebral ischemia;IL-6 |
| Author Name | Affiliation | | GUO Yong-ming | Tianjin University of TCM, Tianjin 300193, China | | LIANG Xian-ru | The Affiliated Hospital of Armed Police Medical College, Tianjin 300162, China |
|
| Abstract
|
| [Objective] To observe the influence of acupuncture on the expression of IL-6 in brain tissue and serum in rats with focal cerebral ischemia.[Method] Focal cerebral ischemia in rat was established by obstructing one side middle cerebral artery with thermocoagulation method,and the expression of IL-6 in brain tissue and serum was measured with radio-immunologic method.[Result] Compared with the normal group,the expression of IL-6 in brain tissue and serum in the ischemia group at 3,6,12,24 hours after cerebral ischemia was all significantly increased(P<0.01).Compared with the ischemia group at the same time periods,the IL-6 expression in brain tissue in the acupuncture group at 3,6,12 hours after acupuncture treatment was significantly reduced(P<0.01),and was obviously lower than that in normal group(P<0.01).After cerebral ischemia,the serum IL-6 expression sharply increased after three hours.Compared with the sham operation group and the normal group at the same time periods,the serum IL-6 expression in the ischemia group at 3,6,12 hours was significantly increased(P<0.01).Compared with the ischemia group at the same time periods,the serum IL-6 content in the acupuncture group at 3,6,12 hours after treatment was significantly reduced(P<0.01).The serum IL-6 expression in the acupuncture group at 24 and 48 hours was obviously increased,and compared with the normal group and the sham operation group it had significant difference.(P<0.01).[Conclusion] Through regulating IL-6,the acupuncture can exert its anti-inflammatory and neuro-protective effect,and can promote the recovery of the injured neurons.That may be one of the effect mechanisms of acupuncture for treating ischemic cerebral apoplexy. |
|
|
|
|
|
|
|
