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| Effect of Huazhuo Tongmai Powder on expression of VEGF and the serum lipid changes of ASO rabbit |
| Hits 1917 Download times 1873 Received:May 20, 2010 |
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| DOI
10.11656/j.issn.1672-1519.2010.06.22 |
| Key Words
Huazhuo Tongmai Powder;Arteriosclerosis obliterans;serum lipid;VEGF |
| Author Name | Affiliation | | LI Shen-xian | The Affiliated Shengjing Hospital of Chinese Medical University, Shenyang 110004, China |
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| Abstract
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| [Objective] The effects of Huazhuo Tongmai Powder on the release of vascular endothelial growth factor(VEGF) and serum lipid levels in ASO rabbits were researched and the mechanism was discussed.[Methods] The ASO was reproduced in 40 New Zealand rabbits with high fat diet and femoral artery balloon injury.These rabbits were randomly divided into 4 groups:Huazhuo Tongmai Powder group(A),Aspirin group(B),High fat diet group(C) and sham surgery group(D).The level of TC,TG,HDL-C and LDL-C after drug intervention wase determined.At the end of the experiment the expression of VEGF was measured with immunohistochemical method.[Results] Huazhuo Tongmai Powder could significantly decrease the level of TC,TG and LDL-C(P<0.01),while the effect on HDL-C was not so obvious(P>0.05).It could decrease the local expression of vascular endothelial growth factor(VEGF) of the injured disease area(P<0.01).[Conclusion] Huazhuo Tongmai Powder can decrease serum lipids and the expression of VEGF of injured area.It can protect artery intima and prevent arteriosclerosis obliterans. |
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