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| Effect of sodium tanshinone B on content of glutamate acid and GABA in hippocampus of rats following focal ischemia and reperfusion injury |
| Hits 1619 Download times 1937 Received:June 20, 2010 |
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| DOI
10.11656/j.issn.1672-1519.2010.06.23 |
| Key Words
Ischemia-Reperfusion injury;glutamate acid;HPLC;GABA;hippocampus |
| Author Name | Affiliation | | CAI Qing | The Traditional Chinese Medical College of Tianjin University of TCM, Tianjin 300193, China | | ZHANG Bo-li | Tianjin University of TCM, Tianjin 300193, China | | HUANG Shu-yun | Tianjin University of TCM, Tianjin 300193, China | | 汪涛 | Tianjin University of TCM, Tianjin 300193, China | | 谭俊珍 | The Traditional Chinese Medical College of Tianjin University of TCM, Tianjin 300193, China | | 周涛 | The Traditional Chinese Medical College of Tianjin University of TCM, Tianjin 300193, China | | 李春深 | The Traditional Chinese Medical College of Tianjin University of TCM, Tianjin 300193, China |
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| Abstract
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| [Objective] To investigate the effects of sodium Tanshinone B on the content of glutamate acid(Glu),γ-aminobutyric acid(GABA) in the hippocampus of rat following focal ischemia-reperfusion injury.[Methods] The rat model of focal cerebral ischemia-reperfusion was established with middle cerebral artery occlusion(MCAO) by reversibly inserting a nylon thread.The rats were randomized into sham operated group,model group and sodium Tanshinone B groups.The concentrations of Glutamate and GABA were analyzed with HPLC.[Results] The levels of glutamate and GABA were significantly lower in each sodium Tanshinone group than that of model group.[Conclusion] The results showed that pretreatment with sodium Tan B could significantly decrease the releasing of glutamate and GABA after ischemia-reperfusion injury. |
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