|
| Effect of Zhichuan decoction on airway inflammation and remodeling in asthmatic rats |
| Hits 1606 Download times 1767 Received:June 20, 2010 |
| View Full Text View/Add Comment Download reader |
| DOI
10.11656/j.issn.1672-1519.2010.06.26 |
| Key Words
asthma;airway inflammation;airway remodeling;Zhichuan decoction |
| Author Name | Affiliation | | ZHANG Zhan-feng | The People’s Hospital in Yanling County, Yanling 461200, China | | HUO Bo-ya | The Third Hospital of Liaoning Medical College, Jinzhou 121001, China |
|
| Abstract
|
| [Objective] To investigate the effects of early treatment with Zhichuan decoction on airway inflammation and remodeling in asthmatic rats.[Methods] Forty Sprague-Dawley rats were randomly divided into four groups equally:normal control group,asthmatic group,budesonide aerosol group and Zhichuan decoction group.The model of asthma was established by OVA(ovalbumin) sensitizing and challenging.The differential counts of inflammatory cell in peripheral blood(PB) and bronchoaveolar(BAL) portion were calculated.By hematoxylin and eosin(HE) stain,pathologic changes of lung tissue were observed,the counts of eosinophil(EOS) and the airway thickness were measured.[Results] In asthmatic group,EOS counts in PB,BAL,airway around and the airway thickness were increased significantly when compared with normal control group(P<0.01).After intervention with budesonide aerosol and Zhichuan decoction,the above indicators were significantly decreased when compared with asthmatic models(P<0.01);No significant difference was found between the two treatment groups(P>0.05).[Conclusion] Prolonged allergen exposure can induce chronic asthma,intervention with Zhichuan decoction can inhibit the airway inflammation and prevent airway remodeling. |
|
|
|
|
|
|
|
