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| Assessment of characteristics of pathogenesis of spleen-warm syndrome of TCM in OLETF rats |
| Hits 1510 Download times 1716 Received:July 07, 2010 |
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| DOI
10.11656/j.issn.1672-1519.2010.06.27 |
| Key Words
Pidan;metabolic syndrome;rats with spontaneous Type 2 Diabetes;animal model |
| Author Name | Affiliation | | ZHEN Zhong | Guanganmen Hospital, Beijing 100053, China | | CHANG Bai | The Metabolic Disease Hospital of Tianjin Medical University, Tianjian 300070, China | | LI Min | Guanganmen Hospital, Beijing 100053, China | | 刘文科 | Guanganmen Hospital, Beijing 100053, China | | 李修洋 | Guanganmen Hospital, Beijing 100053, China | | 于波 | Guanganmen Hospital, Beijing 100053, China | | 仝小林 | Guanganmen Hospital, Beijing 100053, China |
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| Abstract
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| [Objective] To observe the characteristics and process of pathogenesis of spontaneous type 2 diabetes rats(OLETF rats).[Methods] The experimental group of OLETF rats and the normal control group of LETO rats were introduced,and the change of body mass,the fat content in abdominal cavity,the rate of fat to weight,oral glucose tolerance test,GIR and blood fat were observed dynamically.[Results] The body mass and the fat content in abdominal cavity of the rats in experimental group were significantly higher than those in the normal control group.Compared with the normal control group,GIR of experimental group decreased.The level of triglyceride,cholesterol,and free fatty acids were also significantly higher than the normal control group.[Conclusion] The process of pathogenesis in OLETF rats clearly indicated the characteristics and process of pathogenesis of metabolic syndrome in "PiDan"(spleen-warm syndrome) of TCM. |
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