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| Effect of Simao Yongan Decoction on vascular endothelial cells function in diabetic rats |
| Hits 1294 Download times 1540 Received:October 10, 2010 |
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| DOI
10.11656/j.issn.1672-1519.2010.06.28 |
| Key Words
Simao yongan decoction;diabetic peripheral vascular disease;vascular endothelial cells function |
| Author Name | Affiliation | | HUANG Jin-wei | Tangshan Worker’s Hospital, Tangshan 063000, China | | CHANG Bai | Metabolic Disease Hospital of Tianjin Medical University, Tianjin 300193, China |
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| Abstract
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| [Objective] To detect the effect of Simao yongan decoction on the function of vascular endothelial cells through.[Methods] Thirty-six males Wistar rats were randomly divided into two groups:normal control group(twelve) and diabetic group.According to blood-glucose and body weight,they were randomly divided into three groups:model group,diabetic group treated with rosiglitazone and diabetic group with Simao yongan decoction.Every rat was respectively measured about their serums sVCAM-1,plasma TNF-α,NO and ET-1.[Results] Compared with control groups,the content of serums sVCAM-1 and plasma TNF-α increased significantly and plasma ET-1 increased slightly,while NO decreased significantly in diabetic rats.As a result,Simao yongan decoction and Rosiglitazone can significantly decreased the content of serum sVCAM-1,plasma TNF-α and plasma ET-1,while increased the content of plasma NO significantly.[Conclusion] Simao yongan decoction can protect the function of vascular endothelial cells and suppress the initiation and progression of atherosclerosis in diabetic rats. |
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