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| Investigation of Labrasol on the corneal permeability of puerarin in vitro |
| Hits 1583 Download times 2240 Received:June 07, 2010 |
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| DOI
10.11656/j.issn.1672-1519.2010.06.31 |
| Key Words
Labrasol;puerarin;corneal permeability |
| Author Name | Affiliation | | SHU Le-xin | Tianjin University of TCM, Engineering Research Center of Modern Chinese Medicine Discovery and Preparation Technique, Ministryof Education, Tianjin 300193, China | | ZHAO Qi-duo | Tianjin University of TCM, Institute of Pharmacy, Tianjin 300193, China | | LIU Zhi-dong | Tianjin University of TCM, Engineering Research Center of Modern Chinese Medicine Discovery and Preparation Technique, Ministryof Education, Tianjin 300193, China | | 李琳 | Tianjin University of TCM, Engineering Research Center of Modern Chinese Medicine Discovery and Preparation Technique, Ministryof Education, Tianjin 300193, China | | 宋西卫 | Tianjin University of TCM, Engineering Research Center of Modern Chinese Medicine Discovery and Preparation Technique, Ministryof Education, Tianjin 300193, China | | 李楠 | Tianjin University of TCM, Engineering Research Center of Modern Chinese Medicine Discovery and Preparation Technique, Ministryof Education, Tianjin 300193, China |
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| Abstract
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| [Objective] To explore the use of Labrasol in an ocular drug delivery system.[Methods] The effects of Labrasol on the cornealpermeability of puerarin were investigated in vitro,using isolated rabbit corneas.[Results] The 0.5%,1%,1.5%,2%,3% Labrasol showedincrement as much as 1.87,4.41,7.42,8.02 and 9.60 times in the apparent permeability of puerarin,respectively compared with the onesin the control(P<0.01).[Conclustion] The 0.5%～3% Labrasol can enhance the corneal apparent permeability of puerarin significantlyand is not irritant to eye tissues. |
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