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| Brief exploring of hemodynamics in model with Qi stagnation and blood stasis induced by subcutaneous injection of epinephrine |
| Hits 1455 Download times 2000 Received:August 20, 2010 |
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| DOI
10.11656/j.issn.1672-1519.2011.01.04 |
| Key Words
Epinephrine;Qi stagnation and blood stasis;model;hemodynamics |
| Author Name | Affiliation | | ZHANG Zheng-xiang | The First Affiliated Hospital of Zhejiang University of TCM, Zhejiang Provincial Hospital of TCM, Hangzhou 310006, China | | CAO Ke-gang | The Dongzhimen Hospital Affiliated to Beijing University of TCM, Beijing 100700, China | | WANG Fen | The Third Hospital Affiliated to Beijing University of TCM, Beijing 100029, China | | 高永红 | 北京中医药大学东直门医院教育部重点实验室, 北京, 100700 | | 范吉平 | 中国中医科学院, 北京, 100700 |
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| Abstract
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| [Objective] To investigate the hemodynamic changes of Qi stagnation and blood stasis caused by adrenaline injected subcutaneously.[Methods] Twenty-four rats were randomly divided into epinephrine group,normal saline group,normal group.All the rats were continuously monitoring hemodynamic changes of blood flow velocity,heart rate,mean arterial blood pressure for 2 h.[Results] After subcutaneously injection of adrenaline,blood flow velocity of rat common carotid artery(CCA) decreased(P<0.05);heart rate was not significant different with time changing(P>0.05);CCA mean arterial pressure at 120 min was lower than at 40 min(P<0.05).The blood flow in epinephrine group at 60 min,80 min,100 min,120 min was lower than the normal group or the normal saline group(P<0.05).The heart rate in epinephrine group was higher than that of normal saline group at 60 min,80 min and 100 min(P<0.05).CCA mean arterial pressure at 0 min in normal saline group and epinephrine group were lower than normal group(P<0.05).[Conclusion] Blood flow velocity can be used as one of the quantitative evaluation indicators of Qi stagnation and blood stasis caused by adrenaline,One hour after adrenaline injection was a apposite time for screening and evaluating the drug effect of blood-activating and stasis-dissolving with this model. |
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