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| Effect of ginkgo biloba extract EGB761 on the mRNA expression of ACAT1 and LCAT in rabbit with Alzheimer’s disease |
| Hits 1498 Download times 1896 Received:December 20, 2010 |
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| DOI
10.11656/j.issn.1672-1519.2011.01.25 |
| Key Words
ginkgo biloba extract EGB76;Alzheimer’s disease;Lecithin-cholesterol acyl transferase;cholesterol acyltransferase 1 |
| Author Name | Affiliation | | JIANG Xi-juan | 天津中医药大学病理教研室, 天津, 300193 | | LU Bin | 天津中医药大学实验教学部, 天津, 300193 | | MA Dong-ming | 天津中医药大学实验教学部, 天津, 300193 | | 郭茂娟 | 天津中医药大学实验教学部, 天津, 300193 | | 杨琳 | 天津中医药大学实验教学部, 天津, 300193 | | 张瑞峰 | 天津中医药大学病理教研室, 天津, 300193 | | 王强 | 天津中医药大学病理教研室, 天津, 300193 | | 范英昌 | 天津中医药大学病理教研室, 天津, 300193 |
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| Abstract
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| [Objective] To observe whether Ginkgo biloba extract EGB761 can influence the expression of ACAT1 and LCAT mRNA in rabbit with Alzheimer’s disease.[Methods] The male adult New Zealand rabbits were fed by 2% high cholesterol feed in order to establish the model of Alzheimer’s disease.EGB761 was used to treat the rabbits at a dose of 50 mg/(kg·d) for 3 weeks as EGB761 group.Simvastatin was fed at a dose of 5 mg/(kg·d) as a positive control drug.After intervention,the content of lecithin-cholesterol acyl transferase mRNA and cholesterol acyltransferase mRNA in hippocampus was tested by means of real-time quantitative RT-PCR.[Results] The content of ACAT1 mRNA in hippocampus was reduced by Ginkgo biloba extract EGB761,P<0.01 compared with model group.But the content of ACAT1 mRNA was not significant different compared with model group(P>0.05).[Conclusion] Ginkgo biloba extract EGB761 can down-regulate the expression of ACAT1 mRNA in rabbit with Alzheimer’s disease,however,it has no effect on the expression of LCAT mRNA. |
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