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| The effects of pretreatment with acupoint injection of Xiangdan injection at Neiguan(PC6) on TNF-α, VEGF in rats with acute myocardial ischemia |
| Hits 1537 Download times 1746 Received:June 30, 2010 |
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| DOI
10.11656/j.issn.1672-1519.2011.01.28 |
| Key Words
PC6;acupoint injection;preconditioning;myocardial ischemia;TNF-α;VEGF |
| Author Name | Affiliation | | CHEN Qi | People’s Hospital of Chongqing Changshou District, Chongqing 401200, China | | LI Sheng-tao | Huangshi Hospital of TCM in Hubei, Huangshi 435100, China | | CHEN Zhi-wei | Chengdu University of TCM, Chengdu 610075, China |
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| Abstract
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| [Objective] To explore the influence on myocardial ischemia by testing TNF-α and VEGF in the rats pre-injected with XiangDan injection into PC6.[Methods] SD rats were received XiangDan injection into PC6 for 14 days,followed by subcutaneous isoprenaline injection at abdomen to inducing myocardial ischemia.TNF-α and VEGF expression were tested with immunohistochemical assay.[Result] The content of TNF-α was decreased in PC6 group,Drug group and LI11 group.The method of pre-injection of XiangDan injection into PC6 was more effective than Drug group and LI11 group in protecting the myocardium tissue from ischemia and anoxia.The content of VEGF in model group was higher than that of normal group.The content of VEGF was also increased significantly in drug group and LI11 group.Compared with PC6 group statistical significance was obvious.[Conclusions] The method of XiangDan pre-injection into PC6 acupoint can protect the myocardium from ischemia and anoxia.It can decrease the level of TNF-α and increase the contents of VEGF. |
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