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| Effects of Sihui mistura on the behavior responses of sleep-deprived rats in the open field and on the elevated crossed maze |
| Hits 1685 Download times 2115 Received:October 20, 2010 |
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| DOI
10.11656/j.issn.1672-1519.2011.02.22 |
| Key Words
sleep deprivation;open field;elevated crossed maze;Chinese medicine prescription |
| Author Name | Affiliation | | FAN Xin-liu | Beijing University of TCM, Beijing 100029, China | | LI Feng | Beijing University of TCM, Beijing 100029, China | | SONG Yue-han | Beijing University of TCM, Beijing 100029, China | | 关静 | Beijing University of TCM, Beijing 100029, China |
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| Abstract
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| [Objective] To investigate the behavior changes of sleep-deprived rats for 72 h and the influence of three Chinese prescriptions(Sinisan,Shenghuitang,Sihuiheji).[Methods] The behavior change of rats in the open field and on the elevated crossed maze was observed.[Results] After sleep deprivation for 72h,the stay duration and times and standing times in the central area of the open field of rats in model group were significantly higher than that in control.That parameters in rats of Sihuiheji group were all significantly less than that in control group(P<0.05,P<0.01).The OE% on the elevated crossed maze test in model group was markedly higher than that in control group(P<0.05) and that in Sihui mistura was less than that in model group.[Conclusion] Sihui mistura can significantly improve the abnormal changes of anxiety-like behavior and decrease the exploring behavior in sleep-deprived rats.Its effect of is better than Sinisan and Shenghui decoction. |
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