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| Experimental study on the effect of Sanqi flower in treating hypertension |
| Hits 2198 Download times 1961 Received:November 03, 2010 |
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| DOI
10.11656/j.issn.1672-1519.2011.02.23 |
| Key Words
hypertension;Sanchi flower;spontaneous hypertension rats;NO;ET-1;AngⅡ;CGRP;TXB2;6-keto-PGF1α |
| Author Name | Affiliation | | YANG Xing-cai | Shanghai Municipal Hospital of TCM, Shanghai 200071, China | | ZHOU Duan | Longhua Hospital Affiliated to Shanghai University of TCM, Shanghai 200032, China |
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| Abstract
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| [Objective] This study observed the intervention effect of Sanqi(panax notoginseng) flower,a traditional Chinese medicine,on hypertension in the spontaneous hypertension rats(SHRs) and investigated its mechanism preliminarily.[Methods] We used SHRs as experimental animal model,taking the Sanqi flower infusions as the intervention method and Songling Xuemai Kang capsule and Nifedipine as control and taking blood pressure,ET-1,NO,AngⅡ,CGRP,TXB2,6-keto-PGF1α as the observation indexes.The medicines were given daily and for eight weeks.Blood pressure was measured in this duration with the noninvasive tail-volume method four times in all.Finally the other relative blood indexes were measured through sampling from abdominal aorta blood.[Results] 1) The Sanqi flower infusion had corresponding hypotensive effectiveness on certain dose.2) Through the measurement of some plasma active matters it was showed that the hypotensive effectiveness probably had some relation with improvement of vascular endothelial cell function and decreasing plasma ET-1,resuming the balance of vascular constriction and diastolic factors.[Conclusion] The Sanqi flower infusion has corresponding hypotensive effectiveness on hypertension of SHRs.Its hypotensive mechanism probably has some relation with improvement of vascular endothelial cell function and decreasing plasma ET-1,resuming the balance of vascular constriction and diastolic factors. |
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