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| Effects of Tiaoqi xiaoji decoction on immunologic function in mice with Lewis lung cancer |
| Hits 1666 Download times 1534 Received:November 03, 2010 |
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| DOI
10.11656/j.issn.1672-1519.2011.02.24 |
| Key Words
Tiaoqixiaoji decoction;Lewis lung cancer;immunologic function |
| Author Name | Affiliation | | LIANG Jing-jing | TCM Department, Shengjing Hospital of ChinaMedical University, Shenyang 110003, China | | CHEN Su-ning | TCM Department, Shengjing Hospital of ChinaMedical University, Shenyang 110003, China | | SONG Hai-ying | TCM Department, Shengjing Hospital of ChinaMedical University, Shenyang 110003, China | | 蔡玉文 | Liaoning University of TC M, Shenyang 110032, China |
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| Abstract
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| [Objective] To explore the therapeutic effect of Tiaoqixiaoji(regulating Qi and removing food stagnancy) decoction(TQXJ) on the immunologic function in mice with Lewis lung cancer.[Methods] The C57BL/6 mice were inoculated with Lewis lung cancer cells,then randomly divided into: model group(MG),TQXJ group(TG),DDP(Cisplatin) group(DG) and combined TQXJ-DDP group(ZG),with 10 mice in each group;Aanother ten healthy mice were served as control(CG).Different drugs were given to each groups.The index of spleen,the T lymphocyte transformation rate of the peripheral blood,the T lymphocyte proliferation of spleen and expression of tumor necrosis factor-α(TNF-α) of each group were observed.[Results] The decoction of Tiaoqixiaoji could decrease the spleen index of TG and make it proximal to normal value.There was no statistical difference when compared with CG(P>0.05).Observing from the point of view of the T lymphocyte transformation rate and the T lymphocyte proliferation the effect of TG was higher than the MG(P<0.01).The expression of TNF-α was not statistically different between the TG and MG(P>0.05).[Conclusion] TQXJ can protect the immune organ of mice with Lewis lung cancer.It can also improve the immunologic function of the tumor-bearing mice by increasing the T lymphocyte transformation rate of the peripheral blood and the T lymphocyte proliferation of spleen.Hpwever it can not affect the xpression of TNF-α in tumor tissue. |
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