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| Optimization of prescriptions of dispersible tablets of oleanolic acid |
| Hits 2099 Download times 1787 Received:December 05, 2010 |
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| DOI
10.11656/j.issn.1672-1519.2011.02.28 |
| Key Words
dispersible tablets;orthogonal design;dissolution rate;oleanolic acid;HPLC |
| Author Name | Affiliation | | WANG Long | Tianjin University of TCM, Tianjin 300193, China | | MA Li | Tianjin Institude of Pharmaceutical Research, Tianjin 300193, China | | HAN Feng | Tianjin Institude of Pharmaceutical Research, Tianjin 300193, China | | 高静 | Tianjin Institude of Pharmaceutical Research, Tianjin 300193, China |
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| Abstract
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| [Objective] To screen the optimum prescription for oleanolic acid of dispersible tablets by orthogonal design.[Methods] Taking the dissolution rate as an index and using the orthogonal experimental design the prescription match was ultimately determined.[Results] The optimized prescription is: PVPP : CMS-NA : lactose : MCC : silicon gel : PEG-6000=4 : 3 : 30 : 15 : 1 : 1.After optimization the dissolution rate of the dispersible tablets is 89%,showing a significant increasing.[Conclusion] The optimized prescription is reasonable,the technology is feasible.That is tally with the quality requirements of dispersible tablets. |
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