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| Experimental study on controlling symptoms of collagen-induced arthritis with dispelling toxins and dredging collaterals in rats |
| Hits 1621 Download times 2190 Received:March 20, 2011 |
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| DOI
10.11656/j.issn.1672-1519.2011.03.25 |
| Key Words
dispelling toxins and dredging collaterals method;rheumatoid arthritis;collagen-induced arthritis;arthritic symptoms |
| Author Name | Affiliation | | LIU Wei | The First Affiliated Hospital of Tianjin University of TCM, Tianjin 300193, China | | ZHANG Lei | The First Affiliated Hospital of Tianjin University of TCM, Tianjin 300193, China | | WU Yuan-hao | Tianjin University of TCM, Tianjin 300193, China |
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| Abstract
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| [Objective] To explore the controlling effects of dispelling toxins and dredging collaterals on the inflammatory factors of rheumatoid arthritis.[Methods] The model of collagen-induced arthritis (CIA) was duplicated in rats.They were randomly divided into blank group,model control group,Qingbi tablets of low,middle,high dosage groups,positive control group (methylaminopterin group).The administration of drug was started from the 21st day.Beginning at the first day after immunization the arthritis index (AI) was recorded every other day to evaluate the severity of the arthritic development in 4 claws of the rats.Meanwhile,the transverse diameter (TD),anteroposterior diameter (AD) and thick of feet pad (PT) of the rats were measured with a digital caliper.The hind paws were used for radiographic evaluation at the first and the 49th day.[Results] The scores of the X-rays and change of the AI,TD,AD and PT were increased significantly compared with the normal group (P<0.01).The AI of the rats treated with Qingbi tablets of middle and high dosage were decreased significantly compared with the model group (P<0.01).The scores of the X-rays,TD,AD and PT of the rats treated with Qingbi tablets of high dosage were lower significantly compared with the model group (P<0.01),and there was no significant difference of the scores of the X-rays,AI and AD of the rats treated with Qingbi tablets of high dosage compared with positive control group (P>0.05).[Conclusion] The dispelling toxins and dredging collaterals method can protect against inflammation pathological development of CIA rats and relieve inflammatory symptoms. |
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